 | Driver's Ed (2025) as Dr. Goodman |
 | Give Me an A (2023) as Abigail Adams |
 | No Overnight Parking (2023) as Nicole |
 | Who Are You People (2023) as Judith |
 | Hollywood Signs (2022) as Self |
 | Brazen (2022) as Grace Miller |
 | You Are My Home (2020) as Sloane |
 | Tempting Fate (2019) as Gabby Cartwright |
 | Little Italy (2018) as Dora |
 | Alyssa Milano Sex Tape (2013) as Alyssa Milano |
 | Triple Fisher: The Lethal Lolitas of Long Island (2012) as Amy Fisher (archive footage from "Casualties of Love") |
 | New Year's Eve (2011) as Nurse Mindy |
 | Hall Pass (2011) as Mandy |
 | Beverly Hills Chihuahua 2 (2011) as Biminy (voice) |
 | Sundays at Tiffany's (2010) as Jane Claremont |
 | DC Showcase Original Shorts Collection (2010) as Aimee Brenner (segment "The Spectre") (voice) |
 | My Girlfriend's Boyfriend (2010) as Jesse Young |
 | DC Showcase: The Spectre (2010) as Aimee Brenner (voice) |
 | Pathology (2008) as Gwen Williamson |
 | Wisegal (2008) as Patty Montanari |
 | The Blue Hour (2007) as Allegra |
 | Life After Tomorrow (2006) as Self (archive footage) |
 | Blink-182: Greatest Hits (2005) as Josie |
 | Dinotopia: Quest for the Ruby Sunstone (2005) as 26 (voice) |
 | Jimmy Neutron: Win, Lose and Kaboom! (2004) as April (voice) |
 | Dickie Roberts: Former Child Star (2003) as Cyndi |
 | Playboy's 50th Anniversary Celebration (2003) |
 | Kiss The Bride (2002) as Amy Kayne |
 | Buying the Cow (2002) as Amy |
 | The Making of 'Lady and the Tramp II': From Tramp to Scamp (2001) as Self - 'Angel' |
 | Lady and the Tramp II: Scamp's Adventure (2001) as Angel (voice) |
 | Goldrush: A Real Life Alaskan Adventure (1998) as Frances Ella 'Fizzy' Fitz |
 | Hugo Pool (1997) as Hugo Dugay |
 | Below Utopia (1997) as Suzanne |
 | To Brave Alaska (1996) as Denise Harris |
 | Poison Ivy 2: Lily (1996) as Lily |
 | Public Enemies (1996) as Amaryllis |
 | Fear (1996) as Margo Masse |
 | The Surrogate (1995) as Amy Winslow |
 | Deadly Sins (1995) as Cristina |
 | Glory Daze (1995) as Chelsea |
 | Confessions of Sorority Girls (1995) as Rita Summers |
 | Embrace of the Vampire (1995) as Charlotte |
 | Double Dragon (1994) as Marian Delario |
 | Candles in the Dark (1993) as Sylvia Velliste |
 | Conflict of Interest (1993) as Eve |
 | At Home with the Webbers (1993) as Fan |
 | Casualties of Love: The Long Island Lolita Story (1993) as Amy Fisher |
 | Little Sister (1992) as Diana |
 | Where the Day Takes You (1992) as Kimmy |
 | Voices That Care (1991) as Self |
 | The Ice Capades with Jason Bateman and Alyssa Milano (1989) as Host |
 | Speed Zone (1989) as Truck Driver |
 | Alyssa Milano: Look In My Heart (1989) as Herself |
 | Dance 'Til Dawn (1988) as Shelley Sheridan |
 | Crash Course (1988) as Vanessa Crawford |
 | Alyssa Milano's Teen Steam (1988) as Herself |
 | The Canterville Ghost (1986) as Jennifer "Jenny" Canterville |
 | Commando (1985) as Jenny Matrix |
 | Old Enough (1984) as Diane |
| | How the Cookie Crumbles |
| | Alyssa Milano for Mayor |
| | The Night Driver |
| | Who Are You People Executive Producer |
| | Brazen Executive Producer |
 | Surge Executive Producer |
| | Tempting Fate Executive Producer |
| | Sundays at Tiffany's Producer |
| | My Girlfriend's Boyfriend Producer |
| | Wisegal Producer |
| | Below Utopia Executive Producer |
| | Alyssa Milano for Mayor Writer |
| | Alyssa Milano for Mayor Executive Producer |
