 | Avatar 5 (2031) as Neytiri |
 | Avatar 4 (2029) as Neytiri |
 | Avatar: Fire and Ash (2025) as Neytiri |
 | Avatar: A New Era - Special Edition of 20/20 (2025) as Self |
 | Elio (2025) as Olga Solís (voice) |
 | ASCO: Without Permission (2025) |
 | Making Emilia Pérez (2025) as Self |
 | Dovecote (2024) |
 | Emilia Pérez (2024) as Rita |
 | The Absence of Eden (2024) as Esmee / Carmen |
 | Good Burger 2 (2023) as Zoe Saldaña |
 | Disney 100: Remember That (2023) as Self |
 | Marvel Studios Assembled: The Making of the Guardians of the Galaxy Vol. 3 (2023) as Self - 'Gamora' |
 | Guardians of the Galaxy Vol. 3 (2023) as Gamora |
 | Inside Pandora's Box (2023) as Self |
 | Hollywood's Hard Hitters: Women in Action (2023) as Self |
 | Avatar: The Way of Water (2022) as Neytiri |
 | Avatar: The Deep Dive - A Special Edition of 20/20 (2022) as Self |
 | Amsterdam (2022) as Irma St. Clair |
 | The Adam Project (2022) as Laura |
 | Vivo (2021) as Rosa (voice) |
 | Vampires vs. the Bronx (2020) as Becky |
 | Love, Antosha (2019) as Self |
 | This Changes Everything (2019) as Self |
 | Avengers: Endgame (2019) as Gamora |
 | Missing Link (2019) as Adelina Fortnight (voice) |
 | Avengers: Infinity War (2018) as Gamora |
 | I Kill Giants (2017) as Mrs. Mollé |
 | My Little Pony: The Movie (2017) as Captain Celaeno (voice) |
 | Guardians of the Galaxy Vol. 2 (2017) as Gamora |
 | Live by Night (2016) as Graciella Suarez |
 | Quantum Is Calling (2016) as Herself |
 | For the Love of Spock (2016) as Self |
 | Star Trek Beyond (2016) as Lieutenant Nyota Uhura |
 | Nina (2016) as Nina Simone |
 | Sesame Street: Play All Day with Elmo! (2015) as Self |
 | Unity (2015) as Narrator (voice) |
 | The Book of Life (2014) as Maria (voice) |
 | Guardians of the Galaxy (2014) as Gamora |
 | Infinitely Polar Bear (2014) as Maggie |
 | Out of the Furnace (2013) as Lena Taylor |
 | Blood Ties (2013) as Vanessa |
 | Star Trek Into Darkness (2013) as Lieutenant Nyota Uhura |
 | The Words (2012) as Dora Jansen |
 | I Ain't Scared of You: A Tribute to Bernie Mac (2012) as Self |
 | Colombiana (2011) as Cataleya Restrepo |
 | Capturing Avatar (2010) as Self |
 | Takers (2010) as Lilli |
 | The Losers (2010) as Aisha |
 | Burning Palms (2010) as Sarah Cotton |
 | Death at a Funeral (2010) as Elaine |
 | Avatar: Creating the World of Pandora (2010) as Self |
 | Avatar (2009) as Neytiri |
 | Star Trek (2009) as Lieutenant Nyota Uhura |
 | The Skeptic (2009) as Cassie |
 | Vantage Point (2008) as Angie Jones |
 | Blackout (2007) as Claudine |
 | After Sex (2007) as Kat |
 | Constellation (2007) as Rosa Boxer |
 | The Heart Specialist (2006) as Donna |
 | Premium (2006) as Charli |
 | La maldición del Padre Cardona (2005) as Flor |
 | Dirty Deeds (2005) as Rachel Buff |
 | Guess Who (2005) as Theresa Jones |
 | Temptation (2004) as Annie |
 | Haven (2004) as Andrea |
 | The Terminal (2004) as Torres |
 | Pirates of the Caribbean: The Curse of the Black Pearl (2003) as Anamaria |
 | Drumline (2002) as Laila |
 | Crossroads (2002) as Kit |
 | Britney: The Videos (2001) as Self |
 | Britney: The Videos (2001) as Self |
 | Snipes (2001) as Cheryl |
 | Get Over It (2001) as Maggie |
 | Center Stage (2000) as Eva Rodríguez |
| | Sabaya |
| | Don't Forget Me Tomorrow |
| | Riverrun as Dr. Cruz |
| | Positano |
 | Julián Executive Producer |
 | The Bluff Executive Producer |
| | Dovecote Producer |
| | Emilia Pérez Songs |
| | The Absence of Eden Producer |
 | Meet Me in Rome Executive Producer |
 | Meet Me in Paris Executive Producer |
 | 19 Weeks Producer |
 | The Honor List Executive Producer |
 | Kaylien Director |
