| Untitled The Exorcist Film (2027) |
| Anniversary (2025) as Ellen Taylor |
| Inside Out 2 (2024) as Mom (voice) |
| An American Family at 50 (2024) as Self |
| Zack Snyder's Justice League (2021) as Martha Kent |
| Let Him Go (2020) as Margaret Blackledge |
| Ocean Paradise (2019) as Narrator |
| Serenity (2019) as Constance |
| Justice League (2017) as Martha Kent |
| Mark Felt: The Man Who Brought Down the White House (2017) as Audrey Felt |
| Paris Can Wait (2016) as Anne Lockwood |
| Batman v Superman: Dawn of Justice (2016) as Martha Kent |
| Riley's First Date? (2015) as Mom (voice) |
| Trumbo (2015) as Cleo Trumbo |
| Inside Out (2015) as Mom (voice) |
| Every Secret Thing (2014) as Helen Manning |
| James Gandolfini: Tribute to a Friend (2013) as Self |
| Journey of Discovery: Creating Man of Steel (2013) |
| Man of Steel (2013) as Martha Kent |
| Casting By (2012) as Self |
| Half the Sky: Turning Oppression Into Opportunity for Women Worldwide (2012) as Self |
| Final Cut: Hölgyeim és uraim (2012) as (archive footage) |
| Cinema Verite (2011) as Pat Loud |
| Secretariat (2010) as Penny Chenery |
| Killshot (2008) as Carmen Colson |
| Nights in Rodanthe (2008) as Adrienne |
| Jumper (2008) as Mary Rice |
| Untraceable (2008) as Agent Jennifer Marsh |
| Why Be Good?: Sexuality & Censorship in Early Cinema (2007) as Narrator (voice) |
| Fierce People (2006) as Liz Earl |
| Hollywoodland (2006) as Toni Mannix |
| Staying Gold: A Look Back at 'The Outsiders' (2005) as Self |
| On Location in Tulsa: The Making of 'Rumble Fish' (2005) as Self (archive footage) |
| Must Love Dogs (2005) as Sarah |
| Under the Tuscan Sun (2003) as Frances |
| Searching for Debra Winger (2002) as Self |
| Unfaithful (2002) as Constance Sumner |
| Hardball (2001) as Elizabeth Wilkes |
| The Glass House (2001) as Erin Glass |
| The Perfect Storm (2000) as Christina "Chris" Cotter |
| My Dog Skip (2000) as Ellen Morris |
| The Virginian (2000) as Molly Stark |
| The Making of Ladies and Gentlemen, Fabulous Stains (1999) as Self |
| A Walk on the Moon (1999) as Pearl Kantrowitz |
| Grace & Glorie (1998) as Gloria Greenwood |
| Gunshy (1998) as Melissa |
| Murder at 1600 (1997) as Agent Nina Chance |
| The Only Thrill (1997) as Katherine Fritzsimmons |
| Mad Dog Time (1996) as Grace Everly |
| Jack (1996) as Karen Powell |
| Wild Bill (1995) as Susannah Moore |
| A Streetcar Named Desire (1995) as Stella Kowalski |
| Stallone's Law: The Making of 'Judge Dredd' (1995) as Herself |
| Judge Dredd (1995) as Judge Hershey |
| Oldest Living Confederate Widow Tells All (1994) as Lucy Honicut Marsden |
| Indian Summer (1993) as Beth Warden / Clair Everett |
| Chaplin (1992) as Paulette Goddard |
| My New Gun (1992) as Debbie Bender |
| 落陽 (1992) as Lian Hong |
| Knight Moves (1992) as Kathy Sheppard |
| Descending Angel (1990) as Irina Stroia |
| Vital Signs (1990) as Gina Wyler |
| Love Dream (1988) as China |
| The Big Town (1987) as Lorry Dane |
| Lady Beware (1987) as Katya Yarno |
| The Cotton Club (1984) as Vera Cicero |
| Streets of Fire (1984) as Ellen Aim |
| Rumble Fish (1983) as Patty |
| The Outsiders (1983) as Cherry Valance |
| Miss All-American Beauty (1982) as Sally Butterfield |
| Ladies and Gentlemen, the Fabulous Stains (1982) as Corinne Burns |
| Six Pack (1982) as Breezy |
| National Lampoon's Movie Madness (1982) as Liza ("Growing Yourself") |
| Child Bride of Short Creek (1981) as Jessica Rae Jacobs |
| Cattle Annie and Little Britches (1981) as Jenny (Little Britches) |
| Touched by Love (1980) as Karen |
| A Little Romance (1979) as Lauren King |
| Queen City as dian3 |
| Moral Capacity as Dr. Torre |
| Anniversary Executive Producer |