 | You Had to Be There: How the Toronto Godspell Ignited the Comedy Revolution... (2026) as Self |
 | Souvenir (2026) as Cordelia |
 | Stranger Things: Tales from '85 Theatrical Preview (2026) as Anna Baxter (voice) |
 | Roommates (2026) as Professor Ziemann |
 | Boys Go to Jupiter (2025) as Dr. Dolphin (voice) |
 | Tonight's Special with Kareem & Johnny (2025) as Herself |
 | This Is the Tom Green Documentary (2025) as Self (archive footage) |
 | The Apology (2022) as Gretchen Sullivan |
 | The Kids in the Hall: Comedy Punks (2022) as Self |
 | Too Soon: Comedy After 9/11 (2021) as Self |
 | The God Committee (2021) as Dr. Valerie Gilroy |
 | Flora & Ulysses (2021) as Marissa |
 | Asking for It (2020) as Cheryl |
 | Come As You Are (2020) as Liz |
 | 25 Sets (2019) as Self |
 | Other Music (2019) as Self |
 | Mercy Black (2019) as Dr. Ward |
 | It Started As a Joke (2019) as Self |
 | Be Natural: The Untold Story of Alice Guy-Blaché (2018) as Self |
 | A Bread Factory, Part One: For the Sake of Gold (2018) as Jordan |
 | Hurricane Bianca: From Russia with Hate (2018) as Magda |
 | The Happys (2018) as Luann |
 | Submission (2018) as Magda Moynahan |
 | Lovesick Fool - Love in the Age of Like (2018) as Natalie |
 | Sandy Wexler (2017) as Testimonial |
 | Little Boxes (2017) as Helena |
 | Speech & Debate (2017) as Marie |
 | Michael Bolton's Big, Sexy Valentine's Day Special (2017) as Janeane Garofalo |
 | Werewolf Bitches from Outer Space (2017) as Art Gallery Owner |
 | Janeane Garofalo: If I May (2016) as Self |
 | The American Side (2016) as Agent Barry |
 | Sticky: A (Self) Love Story (2016) as Self |
 | Thank You, Del: The Story of the Del Close Marathon (2015) as Self |
 | Hurricane of Fun: The Making of Wet Hot (2015) as Self |
 | 3rd Street Blackout (2015) as June Sherman |
 | Adventures in Comedy (2015) |
 | Misery Loves Comedy (2015) as Self |
 | Free the Nipple (2014) as Anouk |
 | A Little Game (2014) as Sarah Kuftinec |
 | Showing Up (2014) as Self |
 | The Muslims Are Coming! (2013) as Self |
 | Satan, Hold My Hand (2013) as Sheryl |
| | Never Before, Never Again: Behind the Scenes of Asssscat (2013) as Self |
 | Why We Laugh: Funny Women (2013) as Self |
 | Bad Parents (2012) as Kathy |
 | General Education (2012) as Gale Collins |
| | Vanilla Ice Archive (2012) as Self (archive footage) |
 | Mighty Fine (2012) as Narrator (voice) |
 | Janeane Garofalo: If You Will (2010) as Self |
 | I Am Comic (2010) as Self |
 | Love Hurts (2009) as Hannah Rosenbloom |
 | Funny People (2009) as Friend in video (archive footage) (uncredited) |
 | Labor Pains (2009) as Claire |
 | The Guitar (2008) as Dr. Murray |
 | Rain of Madness (2008) as Heidi Bivens |
 | Girl's Best Friend (2008) as Mary |
 | A Bad Situationist (2008) as Lenore Stein |
 | Southland Tales (2007) as General Teena MacArthur |
 | Then She Found Me (2007) as Janeane Garofalo |
 | The Ten (2007) as Beth Soden |
 | Ratatouille (2007) as Colette (voice) |
 | Law Dogs (2007) as Gloria Fontaine |
 | The Making Of 'The Larry Sanders Show' (2007) as Paula |
 | Fuck (2006) as Self |
 | The Wild (2006) as Bridget (voice) |
 | Al Franken: God Spoke (2006) as Self |
 | Duane Hopwood (2005) as Linda |
 | Stay (2005) as Dr. Beth Levy |
 | The Peace Patriots (2005) as Narrator (voice) |
 | Nadine in Dateland (2005) as Nadine |
 | Jiminy Glick in Lalawood (2005) as Dee Dee |
 | Left of the Dial (2005) as Self |
| | Ten Years Later (2005) as Herself |
 | Nobody Knows Anything! (2004) as Patty |
 | Saturday Night Live: The Best of Chris Farley (2003) as Quiz Kings Contestant (archive footage) (uncredited) |
 | Wonderland (2003) as Joy Miller |
 | Outlaw Comic: The Censoring of Bill Hicks (2003) as Self - Host |
 | Dangerous Living: Coming Out in the Developing World (2003) as Narrator (voice) |
 | Gigantic (A Tale of Two Johns) (2003) as Self |
 | The Very Best of America's Funniest Comedians (2003) as Self (archive footage) |
 | Ash Tuesday (2003) as Liz |
 | Manhood (2003) as Jill |
 | When Stand Up Stood Out (2003) as Self |
 | Martin & Orloff (2002) as Hairdresser |
 | Big Trouble (2002) as Monica Romero |
 | The Laramie Project (2002) as Catherine Connolly |
 | The Search for John Gissing (2001) as Linda Barnes |
 | Wet Hot American Summer (2001) as Beth |
 | Laughing Out Loud: America's Funniest Comedians (2001) as Self (archive footage) |
| | Housekeeping (2001) as Hotel Employee ( voice) |
 | The Independent (2000) as Paloma Fineman |
 | Steal This Movie (2000) as Anita Hoffman |
 | The Adventures of Rocky & Bullwinkle (2000) as Minnie Mogul |
 | Titan A.E. (2000) as Stith (voice) |
 | What Planet Are You From? (2000) as Nervous Woman |
 | Behind the Scenes at Daria (2000) as Host |
 | Daring to Resist: Three Women Face the Holocaust (2000) as Narrator |
 | The Bumblebee Flies Anyway (2000) as Dr. Harriman |
 | The N.Y. Friars Club Roast of Jerry Stiller (1999) as Self |
 | Let Me In, I Hear Laughter: A Salute to the Friars Club (1999) as Self |
 | Dogma (1999) as Liz |
 | The Minus Man (1999) as Ferrin |
 | Mystery Men (1999) as Bowler / Carol |
| | MTV's 25 Lamest Videos (1999) as Self / Host |
 | Thick as Thieves (1999) as Anne |
 | 200 Cigarettes (1999) as Ellie |
 | Can't Stop Dancing (1999) as Belinda Peck |
 | Torrance Rises (1999) as Self |
 | The Thin Pink Line (1998) as Joyce Wintergarden-Dingle |
 | Clay Pigeons (1998) as Agent Dale Shelby |
 | Permanent Midnight (1998) as Jana Farmer |
 | Dog Park (1998) as Jeri |
 | Half Baked (1998) as I'm Only Creative When I Smoke Smoker (uncredited) |
 | Saturday Night Live: A Tribute to Chris Farley (1998) as Self |
 | Sweethearts (1997) as Jasmine Pogue |
 | The Matchmaker (1997) as Marcy Tizard |
 | Janeane Garofalo: HBO Comedy Hour (1997) as Self |
 | Cop Land (1997) as Deputy Cindy Betts |
 | Romy and Michele's High School Reunion (1997) as Heather Mooney |
 | Touch (1997) as Kathy Worthington |
 | I Shot a Man in Vegas (1996) as Gale |
 | Larger Than Life (1996) as Mo |
 | The Cable Guy (1996) as Medieval Waitress |
 | The Truth About Cats & Dogs (1996) as Abby |
 | Kids in the Hall: Brain Candy (1996) as Woman at Party |
 | The State's 43rd Annual All-Star Halloween Special (1995) as Self |
 | Now and Then (1995) as Wiladene |
 | Coldblooded (1995) as Honey |
 | HBO Comedy Half-Hour: Janeane Garofalo (1995) as Self |
 | Bye Bye Love (1995) as Lucille |
 | Suspicious (1994) as Woman |
 | Reality Bites (1994) as Vickie Miner |
 | The 15th Annual Young Comedians Show (1992) |
 | Late for Dinner (1991) as Counter Girl |
| | Grind |
 | Romy and Michele 2 as Heather Mooney |
| | Janeane Garofalo: If I May Writer |
| | Janeane Garofalo: If I May Executive Producer |
| | Janeane Garofalo: If You Will Executive Producer |
| | Housekeeping Director |
| | Housekeeping Writer |
| | Sweethearts Producer |
| | Janeane Garofalo: HBO Comedy Hour Writer |
| | Janeane Garofalo: HBO Comedy Hour Executive Producer |
| | HBO Comedy Half-Hour: Janeane Garofalo Writer |
