| Practical Magic 2 (2026) as Sally Owens |
| Sly (2023) as Self (archive footage) (uncredited) |
| Bullet Train (2022) as Maria |
| The Lost City (2022) as Loretta Sage / Angela |
| The Unforgivable (2021) as Ruth Slater |
| Bird Box (2018) as Malorie Hayes |
| Reimagining The Met Gala (2018) as Self |
| Ocean's Team 3.0 (2018) as Self |
| Ocean's Eight (2018) as Debbie Ocean |
| Our Brand Is Crisis (2015) as 'Calamity' Jane Bodine |
| Minions (2015) as Scarlet Overkill (voice) |
| Aningaaq (2013) as Dr. Ryan Stone |
| The Prime Ministers: The Pioneers (2013) as Golda Meir (voice) |
| Gravity (2013) as Ryan Stone |
| The Heat (2013) as Ashburn |
| Extremely Loud & Incredibly Close (2011) as Linda Schell |
| The Blind Side (2009) as Leigh Anne Tuohy |
| All About Steve (2009) as Mary Horowitz |
| The Proposal (2009) as Margaret Tate |
| No Subtitles Necessary: Laszlo & Vilmos (2009) as Self |
| Premonition (2007) as Linda Hanson |
| Infamous (2006) as Nelle Harper Lee |
| Comedy Central Roast of William Shatner (2006) as Self - Filmed Roaster |
| The Lake House (2006) as Dr. Kate Forster |
| Crash (2005) as Jean Cabot |
| Miss Congeniality 2: Armed and Fabulous (2005) as Gracie Hart |
| Loverboy (2005) as Mrs. Harker |
| Two Weeks Notice (2002) as Lucy Kelson |
| Divine Secrets of the Ya-Ya Sisterhood (2002) as Sidda |
| Murder by Numbers (2002) as Cassie Mayweather |
| Miss Congeniality (2000) as Gracie Hart |
| Welcome to Hollywood (2000) as Sandra Bullock |
| Lisa Picard Is Famous (2000) as Sandra Bullock |
| 28 Days (2000) as Gwen Cummings |
| Gun Shy (2000) as Judy Tipp |
| The Prince of Egypt: From Dream to Screen (1999) as Self |
| Forces of Nature (1999) as Sarah Lewis |
| The Worlds of Harry Connick Jr. (1999) as Self |
| The Prince of Egypt (1998) as Miriam (voice) |
| Practical Magic (1998) as Sally Owens |
| Making Sandwiches (1998) as Melba Club |
| Hope Floats (1998) as Birdee Pruitt |
| Speed 2: Cruise Control (1997) as Annie |
| In Love and War (1996) as Agnes von Kurowsky |
| A Time to Kill (1996) as Ellen Roark |
| Two If by Sea (1996) as Roz |
| The Net (1995) as Angela Bennett |
| While You Were Sleeping (1995) as Lucy Eleanor Moderatz |
| Who Do I Gotta Kill? (1994) as Lori |
| Speed (1994) as Annie |
| Wrestling Ernest Hemingway (1993) as Elaine |
| Demolition Man (1993) as Lt. Lenina Huxley |
| Fire on the Amazon (1993) as Alyssa Rothman |
| The Thing Called Love (1993) as Linda Lue Linden |
| When the Party's Over (1993) as Amanda |
| The Vanishing (1993) as Diane Shaver |
| Love Potion No. 9 (1992) as Diane Farrow |
| A Fool and His Money (1989) as Debby Cosgrove |
| The Preppie Murder (1989) as Stacy |
| Who Shot Pat? (1989) as Devlin Moran |
| Bionic Showdown: The Six Million Dollar Man and the Bionic Woman (1989) as Kate Mason |
| Hangmen (1987) as Lisa Edwards |
| Untitled Sandra Bullock & Dana Fox Film |
| Untitled Amazon MGM Romantic Thriller |
| Practical Magic 2 Producer |
| The Lost City Producer |
| The Unforgivable Producer |
| Bird Box Executive Producer |
| Our Brand Is Crisis Executive Producer |
| All About Steve Producer |
| The Proposal Executive Producer |
| Miss Congeniality 2: Armed and Fabulous Producer |
| Sudbury Executive Producer |
| Two Weeks Notice Producer |
| Murder by Numbers Executive Producer |
| Miss Congeniality Producer |
| Gun Shy Producer |
| Making Sandwiches Director |
| Making Sandwiches Writer |
| Hope Floats Executive Producer |
| Mailman Executive Producer |
| Untitled Sandra Bullock & Dana Fox Film Producer |
| Reborn Producer |
| Untitled Amazon MGM Romantic Thriller Producer |