| The New Yorker at 100 (2025) as Self – Narrator (voice) |
| Echo Valley (2025) as Kate Garrett |
| La habitación de al lado (2024) as Ingrid |
| May December (2023) as Gracie |
| Image Book (2023) as Self |
| Sharper (2023) as Madeline Phillips |
| When You Finish Saving the World (2023) as Evelyn |
| Power of Women: The Changemakers (2022) as Self |
| Dear Evan Hansen (2021) as Heidi Hansen |
| With/In Volume 1 (2021) as (segment "Intersection") |
| Spirit Untamed (2021) as Aunt Cora (voice) |
| The Woman in the Window (2021) as Jane Russell 1 (Katie) |
| The Glorias (2020) as Gloria Steinem |
| After the Wedding (2019) as Theresa |
| The Staggering Girl (2019) as Francesca |
| Gloria Bell (2019) as Gloria Bell |
| Bel Canto (2018) as Roxanne Cross |
| Suburbicon (2017) as Margaret Lodge / Rose |
| Wonderstruck (2017) as Lillian Mayhew / Rose |
| Kingsman: The Golden Circle (2017) as Poppy |
| Alec Baldwin: One Night Only (2017) as Self |
| Maggie's Plan (2016) as Georgette Nørgaard |
| Pawns No More: The Making of The Hunger Games: Mockingjay Part 2 (2016) as Self (President Alma Coin) |
| The Hunger Games: Mockingjay - Part 2 (2015) as President Alma Coin |
| Freeheld (2015) as Laurel Hester |
| Straight from the Heart: A Tribute to Philip Seymour Hoffman (2015) as Self |
| The Mockingjay Lives: The Making of the Hunger Games: Mockingjay Part 1 (2015) as Self - President Alma Coin |
| Seventh Son (2014) as Mother Malkin |
| Still Alice (2014) as Alice Howland |
| The Hunger Games: Mockingjay - Part 1 (2014) as President Alma Coin |
| Altman (2014) as Self |
| Maps to the Stars (2014) as Havana Segrand |
| Non-Stop (2014) as Jen Summers |
| 9 Kisses (2014) as Woman in Club |
| Creating Carrie (2014) as Self |
| Carrie (2013) as Margaret White |
| Don Jon (2013) as Esther |
| Find Our Daughter (2013) as Mother |
| The English Teacher (2013) as Linda Sinclair |
| What Maisie Knew (2013) as Susanna |
| Being Flynn (2012) as Jody Flynn |
| Game Change (2012) as Sarah Palin |
| Crazy, Stupid, Love. (2011) as Emily |
| Florent: Queen of the Meat Market (2011) as Self |
| A Child's Garden of Poetry (2011) as Self - Narrator (voice) |
| Elektra Luxx (2011) as Virgin Mary |
| Return to Jurassic Park (2011) as Self |
| The Kids Are All Right (2010) as Jules |
| 6 Souls (2010) as Cara Harding |
| Chloe (2010) as Catherine Stewart |
| A Single Man (2009) as Charley |
| The Private Lives of Pippa Lee (2009) as Kat |
| Eagle Eye (2008) as ARIIA (voice) (uncredited) |
| Blindness (2008) as Doctor's Wife |
| I'm Not There (2007) as Alice Fabian |
| Savage Grace (2007) as Barbara Baekeland |
| Saturday Night Live in the '90s: Pop Culture Nation (2007) as Self |
| Next (2007) as Callie Ferris |
| Children of Men (2006) as Julian |
| Freedomland (2006) as Brenda Martin |
| The Naked Brothers Band: The Movie (2005) as Julianne Moore |
| The Prize Winner of Defiance, Ohio (2005) as Evelyn Ryan |
| Trust the Man (2005) as Rebecca |
| The True Story of Hannibal (2005) as Self |
| The Forgotten (2004) as Telly Paretta |
| Laws of Attraction (2004) as Audrey Woods |
| Marie and Bruce (2004) as Marie |
| Check the Gate: Putting Beckett on Film (2003) as Self - From "Not I"(archive footage) |
| The Hours (2002) as Laura Brown |
| Far from Heaven (2002) as Cathy Whitaker |
| World Traveler (2002) as Dulcie |
| The Shipping News (2001) as Wavey Prowse |
| Breaking the Silence: The Making of Hannibal (2001) as Self |
| Evolution (2001) as Dr. Allison Reed, CDC |
| Hannibal (2001) as Clarice M. Starling |
| Welcome to Hollywood (2000) as Julianne Moore |
| The Ladies Man (2000) as Audrey |
| Psycho Path (2000) as Self - Actress / Lila Crane |
| Not I (2000) as Auditor / Mouth |
| The Beginning of the End of the Affair (2000) as Self |
| That Moment: Magnolia Diary (2000) as Self |
| Magnolia (1999) as Linda Partridge |
| The End of the Affair (1999) as Sarah Miles |
| A Map of the World (1999) as Theresa Collins |
| Cookie's Fortune (1999) as Cora Duvall |
| An Ideal Husband (1999) as Mrs. Laura Cheveley |
| Psycho (1998) as Lila Crane |
| Junket Whore (1998) as Self |
| Chicago Cab (1998) as Distraught Woman |
| The Big Lebowski (1998) as Maude Lebowski |
| Boogie Nights (1997) as Amber Waves |
| The Myth of Fingerprints (1997) as Mia |
| The Lost World: Jurassic Park (1997) as Sarah Harding |
| The Making of 'The Lost World' (1997) as Self |
| Surviving Picasso (1996) as Dora Maar |
| Assassins (1995) as Electra |
| Nine Months (1995) as Rebecca Taylor |
| Safe (1995) as Carol |
| Roommates (1995) as Beth |
| Vanya on 42nd Street (1994) as Yelena |
| Short Cuts (1993) as Marian Wyman |
| The Fugitive (1993) as Anne Eastman |
| Benny & Joon (1993) as Ruthie |
| Luck, Trust & Ketchup: Robert Altman in Carver Country (1993) as Self |
| Body of Evidence (1993) as Sharon Dulaney |
| The Gun in Betty Lou's Handbag (1992) as Elinor |
| The Hand That Rocks the Cradle (1992) as Marlene Craven |
| Cast a Deadly Spell (1991) as Connie Stone |
| The Last to Go (1991) as Marcy |
| Tales from the Darkside: The Movie (1990) as Susan (segment ‘Lot 249’) |
| Money, Power, Murder. (1989) as Peggy Lynn Brady |
| Untitled Julianne Moore/Netflix Film |
| Stone Mattress |
| Control |
| The Debut |
| Cry to Heaven |
| Deux personnes échangeant de la salive Executive Producer |
| Sharper Producer |
| After the Wedding Producer |
| Gloria Bell Executive Producer |
| Marie and Bruce Executive Producer |
| Untitled Julianne Moore/Netflix Film Executive Producer |