Trailer
 | Jason Lee as Shoeshine / Underdog (voice) |
 | Peter Dinklage as Dr. Simon Barsinister |
 | Jim Belushi as Dan Unger |
 | Patrick Warburton as Cad |
 | Alex Neuberger as Jack Unger |
 | Taylor Momsen as Molly |
 | John Slattery as Mayor |
 | Amy Adams as Polly Purebred (voice) |
 | Brad Garrett as Riff Raff (voice) |
 | Samantha Bee as Principal |
 | Timothy Crowe as Police Chief |
 | Larry Vigus as Security Guard |
| Mario Mariani as Police Officer |
 | Bates Wilder as Cop |
| Alexander 'Alex' Garde as Small Boy |
| Christopher Francis Byrnes as Mailman (as Christopher Byrnes) |
| Joe Siriani as News Stand Guy (as Joseph Siriani) |
 | Sujoy De as Office Worker #1 |
 | Michele Proude as Office Worker #2 |
| Albert M. Chan as Geek Worker |
| Jon Pierce as Hot Dog Vendor |
 | Susie Castillo as Diana Flores |
| Bob Jaffe as Professor |
 | Bruce-Robert Serafin as City Worker (as Bruce Serafin) |
 | Lonnie Farmer as Passerby |
 | Anthony Estrella as Male School Teacher (as Tony Estrella) |
| Malik McMullen as Bomb Squad Officer |
| Aaron Dorsey as Little Boy |
| Walter Covell as Old Man |
| Kate Lohman as Housewife |
 | Lewis D. Wheeler as Geek with Glasses |
| Ellen Withrow as Female Teacher |
| John M. Deluca as Newscaster |
 | Frank Ridley as Police Sergeant |
| Grady Justice as College Guy |
| Courtney O'Reagan as College Girl |
| Rebekah Aramini as Fox Collar Lady |
| Richney Fischer as Baseball Dad |
 | Joe Stapleton as Cat Burglar Police #1 |
 | Armen Garo as Cat Burglar Police #2 |
| Daniel Kirby as News Director |
| Stephen James Kidd as Bomb Squad Member (as Steve Kidd) |
 | Rena Maliszewski as Mother |
 | Diana Shneider as Police Secretary |
| Barry Blair as SWAT Captain |
| Bob Boehm as Bomb Squad Officer #2 (as Robert Boehm) |
| Lincoln P. Sisson as Bomb Squad Officer #3 |
| Gabriel Field as Lyle |
| Harry L. Thomas as Police Artist |
| Amy Tanner as Kissing Girl |
| Nicole Kopka as Jogger in Park |
| Adam McCarthy as Capitol City Security |
| Roy Souza as Capitol City Cop |
| Tom Paolino as Capitol City Cop |
| Scott Dittman as Hot Dog Contestant |
 | Ezra Buzzington as Referee |
| Chris Andrew Ciulla as Fireman (as Chris Ciulla) |
 | Jay Leno as Jay Leno |
 | Phil Morris as Supershep 1 (voice) |
 | Michael Massee as Supershep 2 (voice) |
 | Cam Clarke as Little Brown Dog / Supershep 3 (voice) |
 | John DiMaggio as Bulldog / Supershep 4 (voice) |
 | Danny Mastrogiorgio as Crazy Dog (voice) |
 | Jess Harnell as Astronaut (voice) |
 | Joe Bucaro III as Goon #1 |
 | Stuart F. Wilson as Goon #2 |
 | John Franchi as Observer (uncredited) |
 | Susan Garfield as Office Worker (uncredited) |
| Michael Tyler Henry as Jack Unger (voice) |
| Directing | |
| Frederik Du Chau | Director |
Writing | |
| Adam Rifkin | Novel |
| Joe Piscatella | Screenplay |
| Craig A. Williams | Screenplay |
Sound | |
| Randy Edelman | Original Music Composer |
Camera | |
| David Eggby | Director of Photography |
Production | |
| Roger Birnbaum | Producer |
| Jonathan Glickman | Producer |
| Gary Barber | Producer |
Writing | |
| Adam Rifkin | Screenplay |
| Joe Piscatella | Story |
| Craig A. Williams | Story |
| Adam Rifkin | Story |
Production | |
| Eric Ellenbogen | Executive Producer |
| Bob Higgins | Executive Producer |
| Todd Arnow | Executive Producer |
Visual Effects | |
| Hoyt Yeatman | Visual Effects Supervisor |
Production | |
| Erin Stam | Co-Producer |
| Rebekah Rudd | Co-Producer |
| Gail Goldberg | Casting Director |
| Donna E. Bloom | Unit Production Manager |
| Todd Arnow | Unit Production Manager |
Directing | |
| Philip A. Patterson | First Assistant Director |
| Ellen M. Hillers | Second Assistant Director |
Visual Effects | |
| Andy Fowler | Visual Effects Producer |
Crew | |
| Boone Narr | Animal Coordinator |
Costume & Make-Up | |
| Peggy Nicholson | Hair Department Head |
Directing | |
| Kelly Cronin | Script Supervisor |
Sound | |
| Robert L. Sephton | Sound Designer |
| Robert L. Sephton | Supervising Sound Editor |
Crew | |
| Paul J. Lombardi | Special Effects Coordinator |
Production | |
| Montez A. Monroe | Production Coordinator |
Sound | |
| Charles Martin Inouye | Supervising Music Editor |
| Tanya Noel Hill | Music Editor |
Directing | |
| Bob Brown | Second Unit Director |
Visual Effects | |
| Gayle Busby | Visual Effects Producer |
| Rob Duncan | Visual Effects Supervisor |
| Ben Shepherd | Visual Effects Supervisor |
| Mark Dornfeld | Visual Effects Supervisor |
Crew | |
| Lisa Shaftel | Scenic Artist |
| Kimberly Shannon Murphy | Stunts |
| Caroline Vexler | Stunts |
| Aaron Vexler | Stunts |
| Bob Brown | Stunt Coordinator |
| Jon H. Epstein | Stunt Coordinator |
| Shawn Kautz | Stunts |
| Joanne Lamstein | Stunts |
| Ian Mclaughlin | Stunts |
| Stuart F. Wilson | Stunts |
| Jimmy P. Wong | Stunts |
Production | |
| Jay Polstein | Producer |
Editing | |
| Tom Finan | Editor |
Art | |
| Garreth Stover | Production Design |
| James F. Truesdale | Art Direction |
| Maggie Martin | Set Decoration |
Costume & Make-Up | |
| Gary Jones | Costume Design |
| Joe Rossi | Makeup Department Head |
