Trailer
 | Dennis Quaid as Lt. Tuck Pendleton |
 | Martin Short as Jack Putter |
 | Meg Ryan as Lydia Maxwell |
 | Kevin McCarthy as Victor Eugene Scrimshaw |
 | Fiona Lewis as Dr. Margaret Canker |
 | Vernon Wells as Mr. Igoe |
 | Robert Picardo as The Cowboy |
 | Wendy Schaal as Wendy |
 | Harold Sylvester as Pete Blanchard |
 | William Schallert as Dr. Greenbush |
 | Henry Gibson as Mr. Wormwood |
 | John Hora as Ozzie Wexler |
 | Mark L. Taylor as Dr. Niles |
 | Orson Bean as Lydia's Editor |
 | Kevin Hooks as Duane |
 | Kathleen Freeman as Dream Lady |
 | Archie Hahn as Messenger |
 | Dick Miller as Cab Driver |
 | Kenneth Tobey as Man in Restroom |
 | Joe Flaherty as Waiting Room Patient |
 | Andrea Martin as Waiting Room Patient |
 | Jason Laskay as Scrimshaw's Henchman |
| Frank Miller as Scrimshaw's Henchman |
| Shawn Nelson as Wendell |
 | Christine Avila as Lab Technician |
| Alexandra Borrie as Lab Technician |
 | Jenny Gago as Lab Technician |
| Robert Gounley as Lab Technician |
 | Grainger Hines as Rusty |
| Mike Garibaldi as Cop |
 | Richard McGonagle as Cop |
 | Terence McGovern as Travel Agent |
| Robert Neches as Lab Guard |
 | Rance Howard as Supermarket Customer |
 | Chuck Jones as Supermarket Customer |
| Laura Waterbury as Supermarket Customer |
| Kurt Braunreiter as Lab Assault Henchman |
 | Robert Gray as Lab Assault Henchman |
| Brewster Sears as Lab Assault Henchman |
 | Alan Blumenfeld as Man with Camera |
 | Jeffrey Boam as Lydia's Interviewee |
| Sydne Squire as Stewardess |
 | Paul Barselou as Man on Plane |
| John Miranda as Man in Elevator |
| Jordan Benjamin as Little Kid in Mall |
| Roberto Ramirez as Chef |
| Virginia Boyle as Shopping Lady |
 | Herb Mitchell as Camera Store Clerk |
| John Harwood as Lab Henchman |
 | Neil Ross as Pod Computer (voice) |
 | Charles Aidman as Speaker at Banquet |
 | Joe Dante as Vectorscope Employee (uncredited) |
| Directing | |
| Joe Dante | Director |
Sound | |
| Jerry Goldsmith | Original Music Composer |
Writing | |
| Chip Proser | Screenplay |
Crew | |
| Pete Kozachik | Special Effects |
Writing | |
| Jeffrey Boam | Screenplay |
Crew | |
| Mike Johnson | Stunts |
Costume & Make-Up | |
| Rob Bottin | Makeup Effects Designer |
Crew | |
| Corey Michael Eubanks | Stunts |
| Al Wyatt Sr. | Stunts |
| Cindy Wills | Stunts |
| Simone Boisseree | Stunts |
| Dick Warlock | Stunts |
| Steven Lambert | Stunt Double |
Sound | |
| Rod Stewart | Songs |
Visual Effects | |
| Michael Wood | Special Effects Supervisor |
| Dennis Muren | Visual Effects Supervisor |
Camera | |
| Andrew Laszlo | Director of Photography |
Crew | |
| Glenn Randall Jr. | Stunt Coordinator |
Costume & Make-Up | |
| Rosanna Norton | Costume Design |
Art | |
| Gene Nollman | Set Designer |
Costume & Make-Up | |
| John Rizzo | Makeup Artist |
Production | |
| Jon Peters | Executive Producer |
| Steven Spielberg | Executive Producer |
Directing | |
| Carol Green | Second Assistant Director |
Sound | |
| Elliot Tyson | Sound Re-Recording Mixer |
Camera | |
| Ray Kinzer | Key Grip |
Art | |
| Wayne Fitzgerald | Title Designer |
Production | |
| Mike Fenton | Casting |
Sound | |
| Wayne Allwine | Sound Editor |
Editing | |
| Terry Haggar | Color Timer |
Art | |
| Judy Cammer | Set Designer |
| Richard C. Goddard | Set Decoration |
Production | |
| Frank Marshall | Co-Executive Producer |
Directing | |
| Anne Warner | Script Supervisor |
Sound | |
| Warren Hamilton Jr. | Sound Editor |
Costume & Make-Up | |
| Stephen Abrums | Makeup Artist |
Sound | |
| Teresa Eckton | Sound Editor |
Costume & Make-Up | |
| Joy Zapata | Hairstylist |
Directing | |
| Pat Kehoe | First Assistant Director |
Editing | |
| Mark Goldblatt | Additional Editor |
Sound | |
| Douglas Vaughan | Boom Operator |
Costume & Make-Up | |
| Barbara Lorenz | Hairstylist |
Art | |
| David Oliver Pfeil | Title Designer |
Production | |
| Kathleen Kennedy | Co-Executive Producer |
Writing | |
| Chip Proser | Story |
Production | |
| John C. Broderick | Unit Production Manager |
Sound | |
| Ken King | Production Sound Mixer |
Production | |
| Jane Feinberg | Casting |
| Judy Taylor | Casting |
| Chip Proser | Co-Producer |
Sound | |
| Mark Mangini | Supervising Sound Editor |
| John Pospisil | Sound Editor |
| James Matheny | Sound Editor |
Editing | |
| Kent Beyda | Editor |
Art | |
| James H. Spencer | Production Design |
Sound | |
| Kenneth Hall | Music Editor |
Production | |
| Peter Guber | Executive Producer |
| Michael Finnell | Producer |
Lighting | |
| James Plannette | Gaffer |
Art | |
| Craig Raiche | Property Master |
| William F. Matthews | Art Direction |
Sound | |
| Robert J. Litt | Sound Re-Recording Mixer |
| Steve Maslow | Sound Re-Recording Mixer |
Art | |
| Michael Muscarella | Construction Coordinator |
Crew | |
| Julius LeFlore | Stunts |
Directing | |
| Glenn Randall Jr. | Second Unit Director |
Crew | |
| Steven Spielberg | Presenter |
| Harley Jessup | Visual Effects Art Director |
Visual Effects | |
| Pete Kozachik | Visual Effects Camera |
| John Knoll | Visual Effects Camera |
