Trailer
 | Kamal Haasan as Govindarajan Ramaswamy / Rangaraja Nambi / George W. Bush / Avtaar Singh / Balram Naidu / Christian Fletcher / Shinghen Narahasi / Krishnaveni / Vincent Poovaragavan / Kalifullah Mukhtaar |
 | Asin Thottumkal as Kodhai Radha / Andal |
 | Mallika Sherawat as Jasmine |
 | Jaya Prada as Ranjitha Singh |
 | Napoleon as Kulothunga Chola II |
 | P. Vasu as J. Ragavendra (Jaa Raa) |
 | Raghuram as Appa Rao |
 | Nagesh as Sheikh Mukhtaar |
 | Chakri Toleti as Sairam |
 | Shammu as Assistant Biotechnologist |
 | M. S. Bhaskar as Broadway Kumar |
 | Vaiyapuri as Prabhu |
 | Chitti Babu as Ekambaram |
 | Santhana Bharathi as J. Ragavendra's brother-in-law |
 | Sundarrajan as Member of Legislative Assembly |
 | K R Vijaya as Megha Mukhtaar |
 | Ramesh Khanna as Doctor |
 | David W. Scott as Lab Tech / Detective |
| Brian Jennings as Chief of Home Land Security |
 | Rekha as Meenakshi Ragavendra |
| Sound | |
| Kamal Haasan | Playback Singer |
| Devi Sri Prasad | Original Music Composer |
Writing | |
| Vairamuthu | Lyricist |
| Vaali | Lyricist |
Sound | |
| Hariharan | Playback Singer |
| Mahalakshmi Iyer | Playback Singer |
| Sadhana Sargam | Playback Singer |
| Pop Shalini | Playback Singer |
| Himesh Reshammiya | Playback Singer |
Directing | |
| K. S. Ravikumar | Director |
Sound | |
| Himesh Reshammiya | Original Music Composer |
Editing | |
| Ashmith Kunder | Editor |
Production | |
| V. Ravichandran | Producer |
Crew | |
| Grady Allen Bishop | Stunt Double |
Writing | |
| Kamal Haasan | Story |
| Kamal Haasan | Screenplay |
| Kamal Haasan | Dialogue |
| Atul Tiwari | Dialogue |
Camera | |
| Ravi Varman | Director of Photography |
Art | |
| M. Prabhaharan | Art Direction |
Costume & Make-Up | |
| Gautami Tadimalla | Costume Design |
Editing | |
| Thanigachalam | Editor |
Costume & Make-Up | |
| Michael Mosher | Special Effects Makeup Artist |
| Ralis Kahn | Special Effects Makeup Artist |
Crew | |
| Kanal Kannan | Stunt Coordinator |
| Andrew Scott Dixon | Stunt Coordinator |
